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Molecular Biophysics, Grenoble, France

The Biophysics platform at Integrated Structural Biology Grenoble (ISBG) and Institut de Biologie Structurale (IBS), Grenoble offers one of the largest ensemble of state-of-the-art technic & methods for in vitro characterising the intrinsic properties of biological macromolecules in solution, biomolecular interactions and their assemblages.

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User Guide

The platform is organised of several technical plateaus managed by scientists, engineers and technicians with technical and methodological know how and expertise, in order to help any scientist to tackle variety of biological questions and projects including stability, homogeneity, oligomeric states, stoichiometry, specificity, affinity, kinetics, and thermodynamics.

The platform offers:

  1. Protein Analysis On Line (HPLC/MALS)
  2. Analytical UltraCentrifugation (AUC)
  3. Surface Plasmon Resonance (SPR)
  4. BioLayer Interferometry (BLI)
  5. Size-Exclusion Chromatography/Multi-Angle Laser Light Scattering (SEC-MALLS)
  6. IsoThermal Calorimetry (ITC)
  7. Fluorescence spectroscopy
  8. Circular Dichroism (CD)
  9. MicroScale Thermophoresis (MST)
  10. Dynamic Light Scattering (DLS)
  11. Mass Photometry 

The platform and its instruments are available for the entire scientific Instruct-ERIC community.

For more details on plateaus, instruments, experts and how to apply & access, please visit the platform webpage.